Adverse Effects with Nucleoside Analogs ("Nukes")

Also see information specifically related to AZT in azt.html.

“Bristol-Myers Squibb Co., the No. 1 maker of cancer drugs, has strengthened the warning on its HIV drug Videx after four patients, who were taking Videx and another top-selling AIDS drug, died of pancreatitis.”                                                            
Bloomberg. 1999 Nov 19.

“The antiretroviral drugs currently licensed in the United Kingdom [June 1996] are zidovudine (azidothymidine [AZT]), zalcitabine (ddC) and didanosine (ddI). All three are nucleoside analogues...All are very toxic. Suppression of bone marrow elements can occur with any of the three, as can peripheral neuropathy [nerve damage].”                      
Ellis CJ, Leung D. Adverse drug reactions in patients with HIV infection. Adverse Drug Reaction Bulletin. 1996 Jun;178:675-8


 
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