“Two popular HIV drugs may cause birth defects and should be avoided by pregnant women until more is known about their effects, German researchers said on [September 28, 1999]. They found the two drugs, both members of a class known as protease inhibitors, caused abnormal eye development in baby rats. Kai Riecke and colleagues at Freie Universitat Berlin gave the two drugs, Merck's indinavir, known as Crixivan, and Abbott Laboratories' Norvir, or ritonavir, to pregnant rats. They had to stop the ritonavir after a week because it made the rats sick. The rats stayed on the indinavir for the full terms of their pregnancies. Seven of the 236 baby rats exposed to indinavir in the womb were born missing one eye, and two of the 113 baby rats exposed to ritonavir had a missing eye, Riecke's team reported. Fur and teeth also developed later than normal in some of them, they said.”     
Reuters. 1999 Sep 28.

“Evidence is emerging that AIDS drugs can cause serious birth defects in a minority of babies born to HIV-positive mothers...[Stephane Blanche of the Necker Hospital in Paris] has examined the cases of around a thousand pregnant women with HIV and found that eight gave birth to babies who, though HIV-negative, suffered from a neurodegenerative condition that kills its victims in infancy...The condition highlighted by Blanche is thought to be caused by abnormalities in mitochondria, the energy "factories" within our cells. The babies' mothers had all taken a combination of the drugs AZT and 3TC from week 32 of their pregnancy.”                                                                                          
Day M. Babies at risk. New Scientist. 1999 Jun 26.